Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia

In the present study, Hu-Mikβ1, a humanized mAb directed at the shared IL-2/IL-15Rβ subunit (CD122) was evaluated in patients with T-cell large granular lymphocytic (T-LGL) leukemia. Hu-Mikβ1 blocked the trans presentation of IL-15 to T cells expressing IL-2/IL-15Rβ and the common γ-chain (CD132), b...

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Detalhes bibliográficos
Main Authors: Waldmann, Thomas A., Conlon, Kevin C., Stewart, Donn M., Worthy, TatYana A., Janik, John E., Fleisher, Thomas A., Albert, Paul S., Figg, William D., Spencer, Shawn D., Raffeld, Mark, Decker, Jean R., Goldman, Carolyn K., Bryant, Bonita R., Petrus, Michael N., Creekmore, Stephen P., Morris, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548167/
https://ncbi.nlm.nih.gov/pubmed/23212516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-450585
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