Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia

Adult T-cell leukemia (ATL) is an aggressive malignancy of CD4(+)CD25(+) lymphocytes caused by human T-cell lymphotropic virus type 1. Currently, there is no accepted curative therapy for ATL. In gene expression profiling, the antiapoptotic protein survivin (BIRC5) demonstrated a striking increase i...

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Détails bibliographiques
Auteurs principaux: Chen, Jing, Pise-Masison, Cynthia A., Shih, Joanna H., Morris, John C., Janik, John E., Conlon, Kevin C., Keating, Anne, Waldmann, Thomas A.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2013
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596962/
https://ncbi.nlm.nih.gov/pubmed/23321252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-427773
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