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YM155 Inhibits Topoisomerase Function

YM155 (Sepantronium bromide) has been evaluated in clinical trials as a survivin suppressant but despite positive signals from early work later studies were negative. Clarifying the mechanism of action of YM155 is important to its further development. YM155 affects cells in a cell cycle specific man...

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Detalhes bibliográficos
Publicado no:Anticancer Drugs
Main Authors: Hong, Mei, Ren, Ming-Qiang, Silva, Jeane, Paul, Ananya, Wilson, W. David, Schroeder, Carsten, Weinberger, Paul, Janik, John, Hao, Zhonglin
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225247/
https://ncbi.nlm.nih.gov/pubmed/27754993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CAD.0000000000000441
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