Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 in cancers

Abstract Protein ubiquitination is a dynamic and reversible process involved in gene transcription, protein metabolism, and cellular apoptosis. Ubiquitin specific proteases (USPs), as the largest family of deubiquitinating enzymes, are able to remove the ubiquitin from target proteins, rescuing them...

Cijeli opis

Bibliografski detalji

Glavni autori:	Xiang Li, Na He, Yan Lv, Haiyue Wang, Ming Zhang, Heiyan Zhai, Zhen Yang, Yi Yang, Dagang Guo, Zhixiang Cao, Yiyou Chen
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2025-04-01
Serija:	Scientific Reports
Teme:	YM155 A broad-spectrum USP inhibitor c-Myc Notch1 Ubiquitin-proteasome pathway
Online pristup:	https://doi.org/10.1038/s41598-025-88761-3
Oznake:	Dodaj oznaku Bez oznaka, Budi prvi tko označuje ovaj zapis!