Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 in cancers

Abstract Protein ubiquitination is a dynamic and reversible process involved in gene transcription, protein metabolism, and cellular apoptosis. Ubiquitin specific proteases (USPs), as the largest family of deubiquitinating enzymes, are able to remove the ubiquitin from target proteins, rescuing them...

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Detalhes bibliográficos

Principais autores:	Xiang Li, Na He, Yan Lv, Haiyue Wang, Ming Zhang, Heiyan Zhai, Zhen Yang, Yi Yang, Dagang Guo, Zhixiang Cao, Yiyou Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-04-01
coleção:	Scientific Reports
Assuntos:	YM155 A broad-spectrum USP inhibitor c-Myc Notch1 Ubiquitin-proteasome pathway
Acesso em linha:	https://doi.org/10.1038/s41598-025-88761-3
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