Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs

BACKGROUND: Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy. We have now investigated the effects of the combination of YM155, a novel small-molecule inhibitor of survivin expression, and platinum compounds (cisplatin and carboplatin) on hu...

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Detalhes bibliográficos
Main Authors: Iwasa, T, Okamoto, I, Takezawa, K, Yamanaka, K, Nakahara, T, Kita, A, Koutoku, H, Sasamata, M, Hatashita, E, Yamada, Y, Kuwata, K, Fukuoka, M, Nakagawa, K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905296/
https://ncbi.nlm.nih.gov/pubmed/20517311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605713
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