Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia

In the present study, Hu-Mikβ1, a humanized mAb directed at the shared IL-2/IL-15Rβ subunit (CD122) was evaluated in patients with T-cell large granular lymphocytic (T-LGL) leukemia. Hu-Mikβ1 blocked the trans presentation of IL-15 to T cells expressing IL-2/IL-15Rβ and the common γ-chain (CD132), b...

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Main Authors: Waldmann, Thomas A., Conlon, Kevin C., Stewart, Donn M., Worthy, TatYana A., Janik, John E., Fleisher, Thomas A., Albert, Paul S., Figg, William D., Spencer, Shawn D., Raffeld, Mark, Decker, Jean R., Goldman, Carolyn K., Bryant, Bonita R., Petrus, Michael N., Creekmore, Stephen P., Morris, John C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2013
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548167/
https://ncbi.nlm.nih.gov/pubmed/23212516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-450585
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