Preclinical and phase I clinical trial of blockade of IL-15 using Mikβ1 monoclonal antibody in T cell large granular lymphocyte leukemia

Twelve patients with T cell large granular lymphocyte leukemia and associated hematocytopenia were treated in a phase I dose-escalation trial with the murine monoclonal antibody Mikβ1. Mikβ1 identifies CD122, the β-subunit shared by the IL-2 and IL-15 receptors. At the doses administered in this stu...

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Bibliographic Details
Main Authors: Morris, John C., Janik, John E., White, Jeffrey D., Fleisher, Thomas A., Brown, Margaret, Tsudo, Mitsuru, Goldman, Carolyn K., Bryant, Bonita, Petrus, Michael, Top, Lois, Lee, Cathryn C., Gao, Wendy, Waldmann, Thomas A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326174/
https://ncbi.nlm.nih.gov/pubmed/16387851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509575103
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