Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart

AIMS: Impaired energy metabolism has been implicated in the pathogenesis of heart failure. Hyperpolarized (13)C magnetic resonance (MR), in which (13)C-labelled metabolites are followed using MR imaging (MRI) or spectroscopy (MRS), has enabled non-invasive assessment of pyruvate metabolism. We inves...

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Main Authors: Schroeder, Marie A., Lau, Angus Z., Chen, Albert P., Gu, Yiping, Nagendran, Jeevan, Barry, Jennifer, Hu, Xudong, Dyck, Jason R.B., Tyler, Damian J., Clarke, Kieran, Connelly, Kim A., Wright, Graham A., Cunningham, Charles H.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Experimental
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547367/
https://ncbi.nlm.nih.gov/pubmed/23258802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurjhf/hfs192
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