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Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart

AIMS: Impaired energy metabolism has been implicated in the pathogenesis of heart failure. Hyperpolarized (13)C magnetic resonance (MR), in which (13)C-labelled metabolites are followed using MR imaging (MRI) or spectroscopy (MRS), has enabled non-invasive assessment of pyruvate metabolism. We inves...

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Detalhes bibliográficos
Main Authors: Schroeder, Marie A., Lau, Angus Z., Chen, Albert P., Gu, Yiping, Nagendran, Jeevan, Barry, Jennifer, Hu, Xudong, Dyck, Jason R.B., Tyler, Damian J., Clarke, Kieran, Connelly, Kim A., Wright, Graham A., Cunningham, Charles H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547367/
https://ncbi.nlm.nih.gov/pubmed/23258802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurjhf/hfs192
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