Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart

AIMS: Impaired energy metabolism has been implicated in the pathogenesis of heart failure. Hyperpolarized (13)C magnetic resonance (MR), in which (13)C-labelled metabolites are followed using MR imaging (MRI) or spectroscopy (MRS), has enabled non-invasive assessment of pyruvate metabolism. We inves...

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Detalles Bibliográficos
Autores principales: Schroeder, Marie A., Lau, Angus Z., Chen, Albert P., Gu, Yiping, Nagendran, Jeevan, Barry, Jennifer, Hu, Xudong, Dyck, Jason R.B., Tyler, Damian J., Clarke, Kieran, Connelly, Kim A., Wright, Graham A., Cunningham, Charles H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
Materias:
Experimental
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547367/
https://ncbi.nlm.nih.gov/pubmed/23258802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurjhf/hfs192
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