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Nickel-Catalyzed Reductive Conjugate Addition to Enones Via Allylnickel Intermediates

An alternative method to copper-catalyzed conjugate addition followed by enolate silylation for the synthesis of β-di-substituted silyl enol ether products (R(1)(R(2))HCCH=C(OSiR(4)(3))R(3)) is presented. This method uses haloarenes instead of nucleophilic aryl reagents. Nickel ligated to either neo...

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Bibliographic Details
Main Authors: Shrestha, Ruja, Dorn, Stephanie C. M., Weix, Daniel J.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547151/
https://ncbi.nlm.nih.gov/pubmed/23270480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja309176h
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