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Nickel-Catalyzed Hydrogenolysis and Conjugate Addition of 2-Hydroxymethylpyridines via Organozinc Intermediates

2-Hydroxymethylpyridines undergo nickel-catalyzed hydrogenolysis upon activation with a chlorophosphate. Reactions employ diethylzinc and are proposed to proceed through secondary benzylzinc reagents. Quenching with deuteromethanol provides straightforward incorporation of a deuterium label in the b...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Hanna, Luke E., Harris, Michael R., Domon, Kenji, Jarvo, Elizabeth R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402844/
https://ncbi.nlm.nih.gov/pubmed/29135261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b03049
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