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Assessing the Chemical Accuracy of Protein Structures via Peptide Acidity
Although the protein native state is a Boltzmann conformational ensemble, practical applications often require a representative model from the most populated region of that distribution. The acidity of the backbone amides, as reflected in hydrogen exchange rates, is exquisitely sensitive to the surr...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3546150/ https://ncbi.nlm.nih.gov/pubmed/23182463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2012.10.005 |
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