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Assessing the Chemical Accuracy of Protein Structures via Peptide Acidity

Although the protein native state is a Boltzmann conformational ensemble, practical applications often require a representative model from the most populated region of that distribution. The acidity of the backbone amides, as reflected in hydrogen exchange rates, is exquisitely sensitive to the surr...

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Autors principals: Anderson, Janet S., Hernández, Griselda, LeMaster, David M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546150/
https://ncbi.nlm.nih.gov/pubmed/23182463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2012.10.005
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