High-Resolution Analysis and Functional Mapping of Cleavage Sites and Substrate Proteins of Furin in the Human Proteome

BACKGROUND: There is a growing appreciation of the role of proteolytic processes in human health and disease, but tools for analysis of such processes on a proteome-wide scale are limited. Furin is a ubiquitous proprotein convertase that cleaves after basic residues and transforms secretory proprote...

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Main Authors: Shiryaev, Sergey A., Chernov, Andrei V., Golubkov, Vladislav S., Thomsen, Elliot R., Chudin, Eugene, Chee, Mark S., Kozlov, Igor A., Strongin, Alex Y., Cieplak, Piotr
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545927/
https://ncbi.nlm.nih.gov/pubmed/23335997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054290
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