The high throughput multiplexed peptide-centric profiling illustrates both the substrate cleavage redundancy and specificity in the MMP family

Matrix metalloproteinases (MMPs) play incompletely understood roles in health and disease. Knowing the MMP cleavage preferences is essential for a better understanding of the MMP functions and design of selective inhibitors. To elucidate the cleavage preferences of MMPs, we employed a high throughpu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chem Biol
Prif Awduron: Kukreja, Muskan, Shiryaev, Sergey A., Cieplak, Piotr, Muranaka, Norihito, Routenberg, David A., Chernov, Andrei V., Kumar, Sonu, Remacle, Albert G., Smith, Jeffrey W., Kozlov, Igor A., Strongin, Alex Y.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546507/
https://ncbi.nlm.nih.gov/pubmed/26256476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.07.008
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