The high throughput multiplexed peptide-centric profiling illustrates both the substrate cleavage redundancy and specificity in the MMP family

Matrix metalloproteinases (MMPs) play incompletely understood roles in health and disease. Knowing the MMP cleavage preferences is essential for a better understanding of the MMP functions and design of selective inhibitors. To elucidate the cleavage preferences of MMPs, we employed a high throughpu...

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Bibliografische gegevens
Gepubliceerd in:Chem Biol
Hoofdauteurs: Kukreja, Muskan, Shiryaev, Sergey A., Cieplak, Piotr, Muranaka, Norihito, Routenberg, David A., Chernov, Andrei V., Kumar, Sonu, Remacle, Albert G., Smith, Jeffrey W., Kozlov, Igor A., Strongin, Alex Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546507/
https://ncbi.nlm.nih.gov/pubmed/26256476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.07.008
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