New Details of HCV NS3/4A Proteinase Functionality Revealed by a High-Throughput Cleavage Assay

BACKGROUND: The hepatitis C virus (HCV) genome encodes a long polyprotein, which is processed by host cell and viral proteases to the individual structural and non-structural (NS) proteins. HCV NS3/4A serine proteinase (NS3/4A) is a non-covalent heterodimer of the N-terminal, ∼180-residue portion of...

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Autors principals: Shiryaev, Sergey A., Thomsen, Elliot R., Cieplak, Piotr, Chudin, Eugene, Cheltsov, Anton V., Chee, Mark S., Kozlov, Igor A., Strongin, Alex Y.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338790/
https://ncbi.nlm.nih.gov/pubmed/22558217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035759
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