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PI3K Synergizes With Loss of PKC to Elicit Apoptosis via the UPR
It is known that Ras mutations, together with loss of PKC, are apoptotic in various types of mammalian cells. The mechanism of how aberrant Ras transmits this apoptotic signaling remains unclear. Using three V12-Ha-ras loop mutants that preferentially bind to and activate one of Ras effectors, we te...
Tallennettuna:
| Päätekijät: | , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3545399/ https://ncbi.nlm.nih.gov/pubmed/19241442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22102 |
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