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PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis
PI3Kδ plays pivotal roles in the maintenance, proliferation and survival of malignant B-lymphocytes. Although not curative, PI3Kδ inhibitors (PI3Kδi) demonstrate impressive clinical efficacy and, alongside other signaling inhibitors, are revolutionizing the treatment of hematological malignancies. H...
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| Publicado no: | Leukemia |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5467045/ https://ncbi.nlm.nih.gov/pubmed/27843137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.333 |
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