PI3K Synergizes With Loss of PKC to Elicit Apoptosis via the UPR

It is known that Ras mutations, together with loss of PKC, are apoptotic in various types of mammalian cells. The mechanism of how aberrant Ras transmits this apoptotic signaling remains unclear. Using three V12-Ha-ras loop mutants that preferentially bind to and activate one of Ras effectors, we te...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Guo, Jinjin, Zhu, Tongbo, Luo, Ling-Yu, Huang, Yi, Sunkavalli, Raja G., Chen, Chang Yan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545399/
https://ncbi.nlm.nih.gov/pubmed/19241442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22102
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