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Erianin induces apoptosis and pyroptosis via MAPK/ERK and PI3K/Akt pathways and synergizes with anlotinib in anaplastic thyroid carcinoma

IntroductionAnaplastic thyroid carcinoma (ATC) is an aggressive thyroid malignancy characterized by rapid progression, resistance to conventional therapies, and poor patient prognosis. There is an urgent need for innovative therapeutic strategies. Erianin, a natural compound derived from Dendrobium,...

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Principais autores: Qiaonan Zhang, Minghan Qiu, Jinpu Liu, Zhanhua Gao, Yuya Liu, Yayun Wang, Ruxue Liu, Zhen Yang, Jie Hao, Ming Gao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-09-01
coleção:Frontiers in Pharmacology
Assuntos:
anaplastic thyroid carcinoma
erianin
caspase-3/GSDME
pyroptosis
anlotinib
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2025.1596873/full
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