OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells

NANOG, OCT4 and SOX2 form the core network of transcription factors supporting embryonic stem (ES) cell self-renewal. While OCT4 and SOX2 expression is relatively uniform, ES cells fluctuate between states of high NANOG expression possessing high self-renewal efficiency, and low NANOG expression exh...

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Main Authors: Navarro, Pablo, Festuccia, Nicola, Colby, Douglas, Gagliardi, Alessia, Mullin, Nicholas P, Zhang, Wensheng, Karwacki-Neisius, Violetta, Osorno, Rodrigo, Kelly, David, Robertson, Morag, Chambers, Ian
Format: Artigo
Language:Inglês
Published: European Molecular Biology Organization 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545296/
https://ncbi.nlm.nih.gov/pubmed/23178592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.321
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