Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog

Embryonic stem cell (ESC) pluripotency is governed by a gene regulatory network centered on the transcription factors Oct4 and Nanog. To date, robust self-renewing ESC states have only been obtained through the chemical inhibition of signaling pathways or enforced transgene expression. Here, we show...

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Main Authors: Karwacki-Neisius, Violetta, Göke, Jonathan, Osorno, Rodrigo, Halbritter, Florian, Ng, Jia Hui, Weiße, Andrea Y., Wong, Frederick C.K., Gagliardi, Alessia, Mullin, Nicholas P., Festuccia, Nicola, Colby, Douglas, Tomlinson, Simon R., Ng, Huck-Hui, Chambers, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650585/
https://ncbi.nlm.nih.gov/pubmed/23642364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.04.023
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