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A peptide-based biosensor assay to detect intracellular Syk kinase activation and inhibition()

Spleen Tyrosine Kinase (Syk) has been implicated in a number of pathologies including cancer and rheumatoid arthritis and thus has been pursued as a novel therapeutic target. Because of the complex relationship between Syk’s auto- and other internal phosphorylation sites, scaffolding proteins, enzym...

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Detalhes bibliográficos
Main Authors: Lipchik, Andrew M., Killins, Renee L., Geahlen, Robert L., Parker, Laurie L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545090/
https://ncbi.nlm.nih.gov/pubmed/22920457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300970h
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