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Time-Resolved Luminescence Detection of Syk Kinase Activity Through Terbium Sensitization

Disruption of regulatory protein phosphorylation can lead to disease, and is particularly prevalent in cancers. Inhibitors that target deregulated kinases are therefore a major focus of chemotherapeutic development. Achieving sensitivity and specificity in high-throughput compatible kinase assays is...

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Detalhes bibliográficos
Main Authors: Lipchik, Andrew M., Parker, Laurie L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632334/
https://ncbi.nlm.nih.gov/pubmed/23414415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac3023422
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