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A peptide biosensor for detecting intracellular Abl kinase activity using MALDI-TOF MS
Many cancers are characterized by changes in protein phosphorylation as a result of kinase dysregulation. Disruption of Abl kinase signaling through the Philadelphia chromosome (causing the Bcr-Abl mutation) in chronic myeloid leukemia (CML) has provided a paradigm for development of kinase inhibito...
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Asıl Yazarlar: | , , , , |
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Materyal Türü: | Artigo |
Dil: | Inglês |
Baskı/Yayın Bilgisi: |
2009
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Konular: | |
Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2808441/ https://ncbi.nlm.nih.gov/pubmed/19818327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2009.09.048 |
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