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A peptide biosensor for detecting intracellular Abl kinase activity using MALDI-TOF MS
Many cancers are characterized by changes in protein phosphorylation as a result of kinase dysregulation. Disruption of Abl kinase signaling through the Philadelphia chromosome (causing the Bcr-Abl mutation) in chronic myeloid leukemia (CML) has provided a paradigm for development of kinase inhibito...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2808441/ https://ncbi.nlm.nih.gov/pubmed/19818327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2009.09.048 |
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