Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex

The metabolism of glucose and glutamine, primary carbon-sources utilized by mitochondria to generate energy and macromolecules for cell growth, is directly regulated by mTORC1. We show that glucose and glutamine, by supplying carbons to the TCA cycle to produce ATP, positively feed back to mTORC1 th...

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Main Authors: Kim, Sang Gyun, Hoffman, Gregory R., Poulogiannis, George, Buel, Gwen R., Jang, Young Jin, Lee, Ki Won, Kim, Bo-Yeon, Erikson, Raymond L., Cantley, Lewis C., Choo, Andrew Y., Blenis, John
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545014/
https://ncbi.nlm.nih.gov/pubmed/23142078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.003
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