inv(16)/t(16;16) acute myeloid leukemia with non–type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations

The inv(16)(p13q22)/t(16;16)(p13;q22) in acute myeloid leukemia results in multiple CBFB-MYH11 fusion transcripts, with type A being most frequent. The biologic and prognostic implications of different fusions are unclear. We analyzed CBFB-MYH11 fusion types in 208 inv(16)/t(16;16) patients with de...

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Bibliografiska uppgifter
Huvudupphovsmän: Schwind, Sebastian, Edwards, Colin G., Nicolet, Deedra, Mrózek, Krzysztof, Maharry, Kati, Wu, Yue-Zhong, Paschka, Peter, Eisfeld, Ann-Kathrin, Hoellerbauer, Pia, Becker, Heiko, Metzeler, Klaus H., Curfman, John, Kohlschmidt, Jessica, Prior, Thomas W., Kolitz, Jonathan E., Blum, William, Pettenati, Mark J., Dal Cin, Paola, Carroll, Andrew J., Caligiuri, Michael A., Larson, Richard A., Volinia, Stefano, Marcucci, Guido, Bloomfield, Clara D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2013
Ämnen:
Myeloid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544117/
https://ncbi.nlm.nih.gov/pubmed/23160462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-442772
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