inv(16)/t(16;16) acute myeloid leukemia with non–type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations

The inv(16)(p13q22)/t(16;16)(p13;q22) in acute myeloid leukemia results in multiple CBFB-MYH11 fusion transcripts, with type A being most frequent. The biologic and prognostic implications of different fusions are unclear. We analyzed CBFB-MYH11 fusion types in 208 inv(16)/t(16;16) patients with de...

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Autors principals: Schwind, Sebastian, Edwards, Colin G., Nicolet, Deedra, Mrózek, Krzysztof, Maharry, Kati, Wu, Yue-Zhong, Paschka, Peter, Eisfeld, Ann-Kathrin, Hoellerbauer, Pia, Becker, Heiko, Metzeler, Klaus H., Curfman, John, Kohlschmidt, Jessica, Prior, Thomas W., Kolitz, Jonathan E., Blum, William, Pettenati, Mark J., Dal Cin, Paola, Carroll, Andrew J., Caligiuri, Michael A., Larson, Richard A., Volinia, Stefano, Marcucci, Guido, Bloomfield, Clara D.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2013
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544117/
https://ncbi.nlm.nih.gov/pubmed/23160462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-442772
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