Chronic Caloric Restriction Preserves Mitochondrial Function in Senescence Without Increasing Mitochondrial Biogenesis

Caloric restriction (CR) mitigates many detrimental effects of aging and prolongs lifespan. CR has been suggested to increase mitochondrial biogenesis, thereby attenuating age-related declines in mitochondrial function; a concept that is challenged by recent studies. Here we show that lifelong CR in...

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Huvudupphovsmän: Lanza, Ian R., Zabielski, Piotrek, Klaus, Katherine A., Morse, Dawn M., Heppelmann, Carrie J., Bergen, H. Robert, Dasari, Surendra, Walrand, Stephane, Short, Kevin R., Johnson, Matthew L., Robinson, Matthew M., Schimke, Jill M., Jakaitis, Daniel R., Asmann, Yan W., Sun, Zhifu, Nair, K. Sreekumaran
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544078/
https://ncbi.nlm.nih.gov/pubmed/23217257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.11.003
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