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Insulin fails to enhance mTOR phosphorylation, mitochondrial protein synthesis, and ATP production in human skeletal muscle without amino acid replacement

Systemic insulin administration causes hypoaminoacidemia by inhibiting protein degradation, which may in turn inhibit muscle protein synthesis (PS). Insulin enhances muscle mitochondrial PS and ATP production when hypoaminoacidemia is prevented by exogenous amino acid (AA) replacement. We determined...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Barazzoni, Rocco, Short, Kevin R., Asmann, Yan, Coenen-Schimke, Jill M., Robinson, Matthew M., Sreekumaran Nair, K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492854/
https://ncbi.nlm.nih.gov/pubmed/22967500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00067.2012
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