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Decline in skeletal muscle mitochondrial function with aging in humans
Cumulative mtDNA damage occurs in aging animals, and mtDNA mutations are reported to accelerate aging in mice. We determined whether aging results in increased DNA oxidative damage and reduced mtDNA abundance and mitochondrial function in skeletal muscle of human subjects. Studies performed in 146 h...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC556267/ https://ncbi.nlm.nih.gov/pubmed/15800038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501559102 |
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