Pak2 Kinase Restrains Mast Cell FcϵRI Receptor Signaling through Modulation of Rho Protein Guanine Nucleotide Exchange Factor (GEF) Activity

p21-activated kinase-1 (Pak1) is a serine/threonine kinase that plays a key role in mediating antigen-stimulated extracellular calcium influx and degranulation in mast cells. Another isoform in this kinase family, Pak2, is expressed at very high levels in mast cells, but its function is unknown. Her...

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Bibliografiske detaljer
Main Authors: Kosoff, Rachelle, Chow, Hoi Yee, Radu, Maria, Chernoff, Jonathan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543047/
https://ncbi.nlm.nih.gov/pubmed/23204526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422295
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