Pak2 Kinase Restrains Mast Cell FcϵRI Receptor Signaling through Modulation of Rho Protein Guanine Nucleotide Exchange Factor (GEF) Activity

p21-activated kinase-1 (Pak1) is a serine/threonine kinase that plays a key role in mediating antigen-stimulated extracellular calcium influx and degranulation in mast cells. Another isoform in this kinase family, Pak2, is expressed at very high levels in mast cells, but its function is unknown. Her...

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Autores principales: Kosoff, Rachelle, Chow, Hoi Yee, Radu, Maria, Chernoff, Jonathan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543047/
https://ncbi.nlm.nih.gov/pubmed/23204526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422295
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