Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction

It is known that loss-of-function mutations in the gene encoding Parkin lead to development of Parkinson disease. Recently, Parkin was found to play an important role in the removal of dysfunctional mitochondria via autophagy in neurons. Although Parkin is expressed in the heart, its functional role...

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Autors principals: Kubli, Dieter A., Zhang, Xiaoxue, Lee, Youngil, Hanna, Rita A., Quinsay, Melissa N., Nguyen, Christine K., Jimenez, Rebecca, Petrosyan, Susanna, Murphy, Anne N., Gustafsson, Åsa B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543040/
https://ncbi.nlm.nih.gov/pubmed/23152496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.411363
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