Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction

It is known that loss-of-function mutations in the gene encoding Parkin lead to development of Parkinson disease. Recently, Parkin was found to play an important role in the removal of dysfunctional mitochondria via autophagy in neurons. Although Parkin is expressed in the heart, its functional role...

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Autori principali: Kubli, Dieter A., Zhang, Xiaoxue, Lee, Youngil, Hanna, Rita A., Quinsay, Melissa N., Nguyen, Christine K., Jimenez, Rebecca, Petrosyan, Susanna, Murphy, Anne N., Gustafsson, Åsa B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543040/
https://ncbi.nlm.nih.gov/pubmed/23152496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.411363
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