Role of Sirtuin 1 in the Regulation of Hepatic Gene Expression by Thyroid Hormone

Sirtuin 1 (SIRT1) is a nuclear deacetylase that modulates lipid metabolism and enhances mitochondrial activity. SIRT1 targets multiple transcription factors and coactivators. Thyroid hormone (T(3)) stimulates the expression of hepatic genes involved in mitochondrial fatty acid oxidation and gluconeo...

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Autors principals: Thakran, Shalini, Sharma, Pragya, Attia, Ramy R., Hori, Roderick T., Deng, Xiong, Elam, Marshall B., Park, Edwards A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Gene Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543030/
https://ncbi.nlm.nih.gov/pubmed/23209300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.437970
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