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Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor

The crucial role of cell signaling in hemostasis is clearly established by the action of the downstream coagulation protease thrombin that cleaves platelet-expressed G-protein-coupled protease activated receptors (PARs). Certain PARs are cleaved by the upstream coagulation proteases factor Xa (Xa) a...

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Autori principali: Riewald, Matthias, Ruf, Wolfram
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC35412/
https://ncbi.nlm.nih.gov/pubmed/11438726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.141126698
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