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Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor

The crucial role of cell signaling in hemostasis is clearly established by the action of the downstream coagulation protease thrombin that cleaves platelet-expressed G-protein-coupled protease activated receptors (PARs). Certain PARs are cleaved by the upstream coagulation proteases factor Xa (Xa) a...

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Bibliografiske detaljer
Main Authors: Riewald, Matthias, Ruf, Wolfram
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC35412/
https://ncbi.nlm.nih.gov/pubmed/11438726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.141126698
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