Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression

The enforcement of sphingosine-1-phosphate (S1P) signaling network protects from radiation-induced pneumonitis. We now demonstrate that, in contrast to early postirradiation period, late postirradiation sphingosine kinase-1 (SphK1) and sphingoid base-1-phosphates are associated with radiation-induce...

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Detalhes bibliográficos
Main Authors: Gorshkova, Irina, Zhou, Tong, Mathew, Biji, Jacobson, Jeffrey R., Takekoshi, Daisuke, Bhattacharya, Palash, Smith, Brett, Aydogan, Bulent, Weichselbaum, Ralph R., Natarajan, Viswanathan, Garcia, Joe G. N., Berdyshev, Evgeny V.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540856/
https://ncbi.nlm.nih.gov/pubmed/22615416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M026039
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