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Water Networks in Fast Proton Transfer During Catalysis by Human Carbonic Anhydrase II()
Variants of human carbonic anhydrase II (HCA II) with amino-acid replacements at residues in contact with water molecules in the active-site cavity have provided insights into the proton transfer rates in this protein environment. X-ray crystallography and (18)O exchange measured by membrane inlet m...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3540201/ https://ncbi.nlm.nih.gov/pubmed/23215152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301099k |
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