Water Networks in Fast Proton Transfer During Catalysis by Human Carbonic Anhydrase II()

Variants of human carbonic anhydrase II (HCA II) with amino-acid replacements at residues in contact with water molecules in the active-site cavity have provided insights into the proton transfer rates in this protein environment. X-ray crystallography and (18)O exchange measured by membrane inlet m...

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Main Authors: Mikulski, Rose, West, Dayne, Sippel, Katherine H., Avvaru, Balendu Sankara, Aggarwal, Mayank, Tu, Chingkuang, McKenna, Robert, Silverman, David N.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540201/
https://ncbi.nlm.nih.gov/pubmed/23215152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301099k
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