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Proton Transfer in Catalysis and the Role of Proton Shuttles in Carbonic Anhydrase

The undisputed role of His64 in proton transfer during catalysis by carbonic anhydrases in the α class has raised questions concerning the details of its mechanism. The highly conserved residues Tyr7, Asn62, and Asn67 in the active-site cavity function to fine tune the properties of proton transfer...

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Detalhes bibliográficos
Main Authors: Mikulski, Rose L., Silverman, David N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818086/
https://ncbi.nlm.nih.gov/pubmed/19679199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2009.08.003
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