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Proton Transfer in Catalysis and the Role of Proton Shuttles in Carbonic Anhydrase
The undisputed role of His64 in proton transfer during catalysis by carbonic anhydrases in the α class has raised questions concerning the details of its mechanism. The highly conserved residues Tyr7, Asn62, and Asn67 in the active-site cavity function to fine tune the properties of proton transfer...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818086/ https://ncbi.nlm.nih.gov/pubmed/19679199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2009.08.003 |
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