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Water Networks in Fast Proton Transfer During Catalysis by Human Carbonic Anhydrase II()
Variants of human carbonic anhydrase II (HCA II) with amino-acid replacements at residues in contact with water molecules in the active-site cavity have provided insights into the proton transfer rates in this protein environment. X-ray crystallography and (18)O exchange measured by membrane inlet m...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3540201/ https://ncbi.nlm.nih.gov/pubmed/23215152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301099k |
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