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Mechanism of Replicative DNA Polymerase Delta Pausing and a Potential Role for DNA Polymerase Kappa in Common Fragile Site Replication
Common fragile sites (CFS) are hotspots of chromosomal breakage, and CFS breakage models involve perturbations of DNA replication. Here, we analyzed the contribution of specific repetitive DNA sequence elements within CFS to the inhibition of DNA synthesis by replicative and specialized DNA polymera...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3540124/ https://ncbi.nlm.nih.gov/pubmed/23174185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.11.016 |
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