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N-Glycosylation of Enhanced Aromatic Sequons to Increase Glycoprotein Stability

N-glycosylation can increase the rate of protein folding, enhance thermodynamic stability, and slow protein unfolding; however, the molecular basis for these effects is incompletely understood. Without clear engineering guidelines, attempts to use N-glycosylation as an approach for stabilizing prote...

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Bibliographic Details
Main Authors: Price, Joshua L., Culyba, Elizabeth K., Chen, Wentao, Murray, Amber N., Hanson, Sarah R., Wong, Chi-Huey, Powers, Evan T., Kelly, Jeffery W.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539202/
https://ncbi.nlm.nih.gov/pubmed/22782562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.22030
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