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Production of Gastrointestinal Tumors in Mice by Modulating Latent Transforming Growth Factor Beta 1 Activation

Transforming growth factor-β (TGF-β) and its signaling pathways are important mediators in the suppression of cancers of the gastrointestinal (GI) tract. TGF-β is released from cells in a latent complex consisting of TGF-β, the TGF-β propeptide (LAP) and a latent TGF-β binding protein (LTBP). We pre...

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Bibliografische gegevens
Hoofdauteurs: Shibahara, Kotaro, Ota, Mitsuhiko, Horiguchi, Masahito, Yoshinaga, Keiji, Melamed, Jonathan, Rifkin, Daniel B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537847/
https://ncbi.nlm.nih.gov/pubmed/23117884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3141
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