Genetic Suppression of Inflammation Blocks the Tumor-Promoting Effects of TGF-β in Gastric Tissue

The contributions of TGF-β signaling to cancer are complex but involve the inflammatory microenvironment as well as cancer cells themselves. In mice encoding a TGF-β mutant that precludes its binding to the latent TGF-β binding protein (Tgfb1(−/C33S)), we observed multiorgan inflammation and an elev...

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Bibliografiske detaljer
Main Authors: Ota, Mitsuhiko, Horiguchi, Masahito, Fang, Victoria, Shibahara, Kotaro, Kadota, Kyuichi, Loomis, Cynthia, Cammer, Michael, Rifkin, Daniel B.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158836/
https://ncbi.nlm.nih.gov/pubmed/24590056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3404
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