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Disruption of the endothelin A receptor in the nephron causes mild fluid volume expansion

BACKGROUND: Endothelin, via endothelin A receptors (ETA), exerts multiple pathologic effects that contribute to disease pathogenesis throughout the body. ETA antagonists ameliorate many experimental diseases and have been extensively utilized in clinical trials. The utility of ETA blockers has been...

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Detalhes bibliográficos
Main Authors: Stuart, Deborah, Rees, Sara, Woodward, Stephanie K, Koesters, Robert, Strait, Kevin A, Kohan, Donald E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537641/
https://ncbi.nlm.nih.gov/pubmed/23217151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2369-13-166
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